Toxoplasma gondii occurs world-wide and is one of the most common parasitic infections in humans. Infection is acquired by ingestion of viable tissue cysts in undercooked meat, or of oocysts excreted by cats and contaminating soil or water1;2. In this paper the feasibility, effectiveness and appropriateness of introducing prenatal or neonatal screening for congenital toxoplasmosis is evaluated, based on the criteria set out for the assessment of a screening programme by the UK National Screening Committee.